HHC Hexahydrocannabinol Synthesis

If you’re searching for information about Hexahydrocannabinol synthesis, you might be ready to get into the science behind the newly rediscovered cannabinoid, Hexahydrocannabinol (HHC). When doing so, you’ll likely come across PubMed.Gov’s “Synthesis and pharmacological properties of 11-hydroxy-3-(1′,1′-dimethylheptyl)hexahydrocannabinol: a high-affinity cannabinoid agonist“, which provides a lot of details about how the synthesis occurs. Their study seems to be the authority on the subject, and was conducted by a Section of Medicinal Chemistry and Pharmacognosy, School of Pharmacy at the University of Connecticut.

Important Details about HHC

In the Abstract, they provide the following information:

Hexahydrocannabinol was synthesized from the known cannabimimetic analog (+/-)-nabilone… and pharmacological activities of the individual enantiomers were evaluated… The racemic 11 alpha-OH diastereomer (2), a reaction side product, was also evaluated in the mouse model. Only small differences in the pharmacological activity of racemic 1 and 2 were found in the above four measures.

The study found:

The (-)-enantiomer was found to be much more potent than the (+)-enantiomer in all the four measures with the potency ratios in the production of catalepsy (RI), hypoactivity (SA), hypothermia (RT), and antinociception (TF) being 93, 143, 186, and 322, respectively.

In gist, studies like this help to push the hemp industry forward, and gear towards safety for all. The synthesis of HHC from industrial hemp is a relatively new field, and more studies are needed. If you have any additional scholarly articles that could be contributed, please let us know by contacting us and allowing us to evaluate your sources.

Hexahydrocannabinol Synthesis