HHC Hexahydrocannabinol Metabolites

In 1991, a study was conducted on Delta-9-tetrahydrocannabinol (delta-9-THC), delta-8-THC, delta-11-tetrahydrocannabinol (delta-11 THC), cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabigerol (CBG) and hexahydrocannabinol were examined in microsomal preparations to see how their metabolism works. The findings are clear:

The results from HHC were very similar to those from THC, namely hydroxylation at C-11 in most species, and the production of high concentrations of 8 alpha-hydroxy-HHC…

By 2020, a new study was released titled, “Identification of Psychoactive Metabolites from Cannabis sativa, Its Smoke, and Other Phytocannabinoids Using Machine Learning and Multivariate Methods“. In it it provides the following:

The literature has numerous reports, which indicate that tetrahydrocannabinol (THC) is the only major psychoactive metabolite in C. sativa…

The structure–activity relationship (SAR) showed that 54 metabolites from C. sativa have high scaffold homology with THC.

So though science is finding more metabolites of the THC variety, only THC Metabolites are the type which could be triggered in most drug tests. As more studies are released, we will learn more about how Hexahydrocannabinol – HHC affects metabolites.

Hexahydrocannabinol Metabolites